Minor
amoxicillin × levothyroxine sodium
Penicillins with extended spectrum×Thyroid hormones
Mechanism
Amoxicillin can interfere with intestinal absorption of levothyroxine when taken simultaneously – clinically insignificant when administration is separated.
Management
Take levothyroxine and amoxicillin at least 2 hours apart.
Sources
- Lexicomp: Lexicomp Drug Interactions (2024)— Wolters Kluwer Clinical Drug Information, Inc. Lexi-Interact Online, 2024
- Pharmaceutical Press: Stockley's Drug Interactions, 12th edition (2024)— Preston CL (ed.). Stockley's Drug Interactions. 12th ed. London: Pharmaceutical Press; 2024