Minor
amoxicillin × metronidazole
Penicillins with extended spectrum×Imidazole derivatives (antiprotozoal / antibacterial)
Mechanism
A target combination in triple/quadruple Helicobacter pylori eradication regimens (Maastricht VI / Florence Consensus 2022, Kyoto Global Consensus, Russian Ministry of Health 2024 guidelines). No direct pharmacokinetic interaction – the two drugs act synergistically against H. pylori.
Management
Standard regimen: omeprazole 20 mg twice daily + amoxicillin 1000 mg twice daily + metronidazole (or clarithromycin) 500 mg twice daily for 14 days.
Sources
- European Helicobacter and Microbiota Study Group: Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report (2022)— Gut 2022;71(9):1724–1762
- Минздрав РФ: Язвенная болезнь желудка и/или двенадцатиперстной кишки у взрослых. Клинические рекомендации (ID 277) (2024)— КР Минздрава РФ, ID 277, 2024