Minor
metformin × omeprazole
Biguanides. Oral antihyperglycemic agents×Proton pump inhibitors
Mechanism
Omeprazole inhibits intestinal OCT1 – metformin absorption rises slightly. Clinical significance is minimal and no additional hypoglycemia occurs.
Management
No dose adjustment is required.
Sources
- Lexicomp: Lexicomp Drug Interactions (2024)— Wolters Kluwer Clinical Drug Information, Inc. Lexi-Interact Online, 2024
- Pharmaceutical Press: Stockley's Drug Interactions, 12th edition (2024)— Preston CL (ed.). Stockley's Drug Interactions. 12th ed. London: Pharmaceutical Press; 2024