INCI: Acetyl Hexapeptide-8
Synthetic peptide, a SNAP-25 fragment. Marketed as 'botox in a jar' – suppresses neurotransmitter release at the neuromuscular junction. In reality, the effect is orders of magnitude weaker than botulinum toxin.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Small industry-sponsored studies show 17–30% reduction in expression wrinkle depth over 30 days. No independent placebo-controlled RCTs. Actual penetration through the stratum corneum is the key question for all peptides.
5–10% solution (0.005–0.05% as peptide)
Irritation potential
LowAllergen risk
LowPregnancy
UnknownSuitable for
Safety data for Acetyl Hexapeptide-8 (Argireline) during pregnancy is insufficient. Best avoided when in doubt.
Acetyl Hexapeptide-8 (Argireline) suits: normal, dry, sensitive, combination, oily.
Synthetic peptide, a SNAP-25 fragment.
The INCI name is Acetyl Hexapeptide-8. It may also appear as: Argireline, Ацетилгексапептид-8, Аргирелин.
5–10% solution (0.005–0.05% as peptide)
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