Synthetic peptide, an elongated analogue of Argireline (Acetyl Hexapeptide-8). The manufacturer Lipotec claims SNARE-complex blockade at facial muscle synapses – a 'mechanism close to botulinum toxin'. Used in anti-age serums to smooth expression lines – glabellar, nasolabial, and outer eye wrinkles. Real effects are substantially weaker than botulinum therapy.
Topical application
DVery weak or conflicting data.
The evidence base consists of manufacturer studies (Lipotec) showing a positive effect on expression lines over 28 days. There are no independent RCTs with head-to-head comparison to botulinum toxin or placebo control. 'Botox in a jar' is marketing – the clinical effect is substantially weaker.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
Acetyl Octapeptide-3 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl Octapeptide-3 suits: normal, dry, combination, sensitive.
Synthetic peptide, an elongated analogue of Argireline (Acetyl Hexapeptide-8).
The INCI name is Acetyl Octapeptide-3. It may also appear as: SNAP-8, Argireless, Ацетил октапептид-3.
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