Acetylated 4-amino-acid peptide – an anti-glycation and anti-puffiness component. Used in products against eye puffiness and dark circles. Pregnancy-safe.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Anti-AGE peptide for the eye area. Moderate evidence.
Acetyl Tetrapeptide-5 (Eyeseryl) is a synthetic acetylated tetrapeptide. INCI: Acetyl Tetrapeptide-5. Developed by Lipotec to reduce puffiness and dark circles around the eyes. In cosmetics it works through several mechanisms: blocks collagen glycation (anti-AGEs), improves lymph drainage, reduces capillary permeability. The manufacturer reports a 17% reduction in visible eye bags after 28 days. Use levels run from 1 to 10% of the commercial solution (containing about 0.05% peptide). Pregnancy safety. Systemic absorption is minimal. Skin profile. Low irritation and allergen potential. Non-comedogenic. Suitable for all skin types. Moderate evidence (B).
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
Acetyl Tetrapeptide-5 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl Tetrapeptide-5 suits: normal, dry, combination, oily, sensitive.
Acetylated 4-amino-acid peptide – an anti-glycation and anti-puffiness component.
On the Fulton scale 0/5 – non-comedogenic. For acne-prone skin, a rating of 3 or higher suggests choosing an alternative.
The INCI name is Acetyl Tetrapeptide-5. It may also appear as: Eyeseryl, ацетил тетрапептид-5.
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