Adenosine

Natural nucleoside acting via skin adenosine receptors. Stimulates collagen synthesis and improves skin firmness.

Evidence by route

Topical application

Limited evidence. One RCT or several controlled studies with limitations.

Several small clinical studies at 0.04% show modest wrinkle reduction. Manufacturer-sponsored data predominate. Independent large RCTs are absent. Mechanism of collagenogenesis stimulation via A2a receptors is established in vitro.

Lee KS et al. Arch Dermatol Res. 2009;301(4):305-313.

Working concentrations

0.04%

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Unknown

Skin types

Suitable for

NormalDrySensitiveCombination

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Frequently asked questions

Is Adenosine safe during pregnancy?

Safety data for Adenosine during pregnancy is insufficient. Best avoided when in doubt.

What skin types is Adenosine for?

Adenosine suits: normal, dry, sensitive, combination.

What is Adenosine and what does it do in cosmetics?

Natural nucleoside acting via skin adenosine receptors.

What's the INCI name for Adenosine?

The INCI name is Adenosine. It may also appear as: Аденозин.

What concentration of Adenosine is effective?

0.04%

Published: April 13, 2026 · updated: April 22, 2026