Copper Peptides (GHK-Cu)

INCI: Copper Tripeptide-1

Tripeptide-copper complex that stimulates synthesis of collagen, elastin, and glycosaminoglycans. Accelerates wound healing and exerts anti-inflammatory effects.

Anti-aging Soothing

Evidence by route

Topical application

Limited evidence. One RCT or several controlled studies with limitations.

Wound and post-surgical studies show accelerated regeneration. Anti-aging RCTs are limited by small samples and industry sponsorship. In vitro effects are well documented, but more large clinical trials are needed.

Pickart L et al. Int J Mol Sci. 2012;13(5):6229-6240.
Leyden JJ et al. J Cosmet Dermatol. 2004;3(1):26-31.

Working concentrations

0.1–1% (as peptide)

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Unknown

Skin types

Suitable for

NormalDrySensitiveCombination

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Combinations with other ingredients

Does not combine with

L-Ascorbic Acid (Vitamin C)L-Аскорбиновая кислота (витамин C)

Vitamin C reduces copper in GHK-Cu, breaking the peptide. Use at different times: C in morning, copper peptides in evening.

Frequently asked questions

Is Copper Peptides (GHK-Cu) safe during pregnancy?

Safety data for Copper Peptides (GHK-Cu) during pregnancy is insufficient. Best avoided when in doubt.

What skin types is Copper Peptides (GHK-Cu) for?

Copper Peptides (GHK-Cu) suits: normal, dry, sensitive, combination.

What is Copper Peptides (GHK-Cu) and what does it do in cosmetics?

Tripeptide-copper complex that stimulates synthesis of collagen, elastin, and glycosaminoglycans.

What's the INCI name for Copper Peptides (GHK-Cu)?

The INCI name is Copper Tripeptide-1. It may also appear as: GHK-Cu, Copper Peptides, Медные пептиды.

What concentration of Copper Peptides (GHK-Cu) is effective?

0.1–1% (as peptide)

Published: April 13, 2026 · updated: May 18, 2026