A chalcone from liquorice root (Glycyrrhiza inflata). Acts on multiple inflammation pathways: inhibits NF-κB and suppresses pro-inflammatory cytokines (IL-6, TNF-α). In clinical studies it shows effects in rosacea and sensitive skin, and inhibits Propionibacterium acnes growth. Key active in the Eucerin Anti-Redness and Eucerin Dermo-Pure lines.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Several clinical studies show erythema reduction in rosacea and sensitive skin, and reduction in papule counts in acne. Effects are modest but consistent. Complements mainstream approaches (metronidazole and ivermectin for rosacea, BPO and adapalene for acne) but does not replace them.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
Licochalcone A is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Licochalcone A suits: normal, dry, combination, oily, sensitive.
A chalcone from liquorice root (Glycyrrhiza inflata).
The INCI name is Licochalcone A. It may also appear as: Glycyrrhiza Inflata Root Extract, Ликохалкон А, Глицирризиновая солодка.
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