Synthetic 9-amino-acid peptide – an α-MSH receptor inhibitor, a brightening component. Reduces melanin synthesis in melanocytes. Pregnancy-safe.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Brightening peptide with confirmed α-MSH inhibition mechanism.
Nonapeptide-1 (Melitane) is a synthetic 9-amino-acid peptide, an antagonist of α-melanocyte-stimulating hormone (α-MSH). INCI: Nonapeptide-1. In cosmetics it works as a brightening agent. It blocks the α-MSH receptor MC1R on melanocytes, which reduces tyrosinase activation and melanin synthesis. An alternative to hydroquinone without irritating action. Used in products for hyperpigmentation, melasma and post-inflammatory spots. Use levels run from 0.1 to 2% active peptide. Pregnancy safety. Skin absorption into the systemic circulation is minimal. Skin profile. Low irritation and allergen potential. Non-comedogenic. Suitable for all skin types. Moderate evidence (B) – in vitro and small clinical data from the manufacturer.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
Nonapeptide-1 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Nonapeptide-1 suits: normal, dry, combination, oily, sensitive.
Synthetic 9-amino-acid peptide – an α-MSH receptor inhibitor, a brightening component.
On the Fulton scale 0/5 – non-comedogenic. For acne-prone skin, a rating of 3 or higher suggests choosing an alternative.
The INCI name is Nonapeptide-1. It may also appear as: Melitane, нонапептид-1.
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