Synthetic lipopeptide of six amino acids with a palmitic tail for better penetration. The manufacturer claims stimulation of collagen and glycosaminoglycan synthesis and wrinkle smoothing. Part of well-known anti-age complexes (Matrixyl synthe'6). Belongs to the 'signalling peptide' class.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Signalling peptides as a class show a modest clinical effect in a few RCTs. For Palmitoyl Hexapeptide-12 there are no head-to-head comparisons with retinol or vitamin C in independent studies. The evidence base is primarily manufacturer-led (Sederma) with moderate methodology.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
Palmitoyl Hexapeptide-12 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Palmitoyl Hexapeptide-12 suits: normal, dry, combination, sensitive.
Synthetic lipopeptide of six amino acids with a palmitic tail for better penetration.
The INCI name is Palmitoyl Hexapeptide-12. It may also appear as: Пальмитоил гексапептид-12.
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