INCI: Palmitoyl Pentapeptide-4
Synthetic peptide mimicking a type I collagen fragment. Activates synthesis of collagen, fibronectin, and hyaluronic acid via dermal cell signaling pathways.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Data from two small sponsor-conducted clinical studies demonstrate wrinkle reduction and improved skin firmness. Independent RCTs are absent. In vitro data confirm collagenogenesis stimulation. Actual peptide penetration through the stratum corneum remains debated.
0.005–0.01% (as active peptide)
Irritation potential
LowAllergen risk
LowPregnancy
UnknownSuitable for
Safety data for Matrixyl (Palmitoyl Pentapeptide-4) during pregnancy is insufficient. Best avoided when in doubt.
Matrixyl (Palmitoyl Pentapeptide-4) suits: normal, dry, sensitive, combination.
Synthetic peptide mimicking a type I collagen fragment.
The INCI name is Palmitoyl Pentapeptide-4. It may also appear as: Matrixyl, Pal-KTTKS, Пальмитоил пентапептид-4.
0.005–0.01% (as active peptide)
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