Palmitoyl Tripeptide-5

Peptide mimicking TSP-1 – an activator of latent TGF-β. Stimulates collagen synthesis in vitro. One of the better-studied cosmetic peptides.

Evidence by route

Topical application

Weak evidence. In vitro data, open-label studies, or expert consensus.

Accumulated in vitro data on collagen stimulation. Small human studies show positive effects on wrinkles.

Irritation potential

Low

Allergen risk

Low

Pregnancy

Caution

Suitable for

NormalDryOilyCombination

Use with caution

Sensitive

Is Palmitoyl Tripeptide-5 safe during pregnancy?

Palmitoyl Tripeptide-5 should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.

What skin types is Palmitoyl Tripeptide-5 for?

Palmitoyl Tripeptide-5 suits: normal, dry, oily, combination. Use with caution in: sensitive.

What is Palmitoyl Tripeptide-5 and what does it do in cosmetics?

Peptide mimicking TSP-1 – an activator of latent TGF-β.

What's the INCI name for Palmitoyl Tripeptide-5?

The INCI name is Palmitoyl Tripeptide-5. It may also appear as: Syn-Coll.

Published: May 14, 2026 · updated: May 17, 2026