Water-soluble vitamin B5, biochemical precursor of coenzyme A. Cosmetics more often use the proalcohol form D-Panthenol (dexpanthenol), which converts to pantothenic acid on skin. The acid itself is used less often – it is unstable in aqueous formulas, and D-Panthenol has better penetration. In acne and post-procedure skin, pantothenate stimulates reparative processes in keratinocytes.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Pantothenic acid and D-panthenol have shown effects on wound healing, irritation reduction, and barrier support in controlled studies. D-panthenol performs better in head-to-head comparisons – its proalcohol form penetrates the stratum corneum more efficiently. For extension labelling both names need to be recognised.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
Pantothenic Acid is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Pantothenic Acid suits: normal, dry, combination, oily, sensitive.
Water-soluble vitamin B5, biochemical precursor of coenzyme A.
The INCI name is Pantothenic Acid. It may also appear as: Vitamin B5, Пантотеновая кислота, Витамин B5.
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