Zinc PCA

Zinc salt of pyrrolidone carboxylic acid (NMF). A seboregulator that reduces sebum production. Used in products for oily skin and acne.

Acne

Evidence by route

Topical application

Weak evidence. In vitro data, open-label studies, or expert consensus.

Small clinical studies show 20–30% sebum reduction with daily use. Zinc's antibacterial activity against C. acnes confirmed in vitro. No large comparative RCTs.

Piérard-Franchimont C et al. Dermatology. 2000;200(3):244-246.

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Safe

Skin types

Suitable for

OilyCombination

Use with caution

Dry

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Combinations with other ingredients

Works well with

NiacinamideНиацинамид

Combination reduces sebum production and inflammation. Niacinamide regulates the barrier, zinc binds excess sebum.

Frequently asked questions

Is Zinc PCA safe during pregnancy?

Zinc PCA is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.

What skin types is Zinc PCA for?

Zinc PCA suits: oily, combination. Use with caution in: dry.

What is Zinc PCA and what does it do in cosmetics?

Zinc salt of pyrrolidone carboxylic acid (NMF).

What's the INCI name for Zinc PCA?

The INCI name is Zinc PCA. It may also appear as: Цинк PCA.

Published: April 13, 2026 · updated: April 22, 2026