Minor
Alprazolam × Digoxin
Benzodiazepines. Short-to-medium-acting anxiolytics×Cardiac glycosides (digitalis)
Mechanism
No direct pharmacokinetic or pharmacodynamic interaction. Isolated reports of slight digoxin elevation in older patients, without clinical significance.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
No dose adjustment needed. In older patients on digoxin, watch for alprazolam sedation signs.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.