Moderate
Budesonide × clonidine
Inhaled corticosteroids (ICS)×Central α2-adrenergic agonist
Mechanism
Systemic budesonide retains sodium and water via mineralocorticoid effect, blunting clonidine's antihypertensive effect. Inhaled budesonide does not clinically affect BP.
Symptoms
On long-term systemic therapy: return or rise of blood pressure, leg oedema.
Management
For short systemic budesonide courses, no specific adjustment needed. For long-term therapy, check BP weekly in the first month. If BP rises, increase clonidine or add a diuretic. Inhaled budesonide with clonidine is unproblematic.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.