Major
Colchicine × Dronedarone
Antigout agents×Class III antiarrhythmic
Mechanism
Dronedarone strongly blocks both P-glycoprotein and CYP3A4 – two colchicine clearance routes. Colchicine plasma levels rise; myopathy, neuropathy, and pancytopenia risks grow.
Symptoms
Profuse diarrhoea, vomiting, abdominal pain. With prolonged combination: muscle weakness, peripheral neuropathy, falling leukocytes and platelets.
Management
In chronic kidney disease or hepatic impairment, do not prescribe the combination. With preserved function: colchicine 0.3 mg every other day for no more than 5 days. Alternative for gout on dronedarone: intra-articular or short systemic glucocorticoid.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.