Curcumina (extracto de Curcuma longa)

Curcumin (Curcuma longa extract) is evaluated for the following indications with varying evidence strength: Ulcerative colitis remission maintenance (evidence tier D), Knee osteoarthritis (evidence tier D), Cancer prevention (evidence tier F). See the full indication matrix with dosing and citations above on this page.

Common side effects of Curcumin (Curcuma longa extract) (≥ 1 in 100): Nausea, epigastric discomfort, Diarrhoea at high doses, Yellow stool discoloration. See the Safety section for uncommon and serious reactions.

FDA category C. Turmeric at culinary doses is safe. High-dose curcumin supplements in pregnancy are not recommended – there are theoretical data on uterine contractility stimulation and bleeding risk.

Turmeric at culinary doses is safe. High-dose curcumin supplements during breastfeeding are not recommended.

Curcumin (Curcuma longa extract) is contraindicated in: Hypersensitivity to curcumin or turmeric; Pregnancy and breastfeeding; Active cholelithiasis; Acute cholangitis, biliary obstruction; Severe liver disease. Full list in the Safety section.

laboratory data on antitumour, anti-inflammatory, and neuroprotective effects do not translate to clinical practice. Pure curcumin bioavailability is less than 1%, and systemic concentrations at standard doses are insufficient to reproduce in vitro effects.

piperine increases curcumin bioavailability 20-fold, but is also a potent CYP3A4 and P-glycoprotein inhibitor. This creates a risk of drug interactions with many medicines (statins, immunosuppressants, antidepressants, warfarin). In polypharmacy, the curcumin+piperine combination requires caution.

the effect of dietary turmeric on joints is clinically minor. The curcuminoid dose in a standard cup of golden milk is 50–100 mg, 5–15 times less than RCT-tested doses. With osteoarthritis and pain, consult a clinician for standard therapy, not spices.