Third-generation synthetic retinoid. Photostable, less irritating than tretinoin. Available OTC at 0.1% concentration (Differin).
Topical application
AProven efficacy. Two or more independent RCTs with instrumental endpoints.
Meta-analyses confirm acne efficacy comparable to tretinoin with better tolerability. FDA approved 0.1% as OTC acne treatment. Less photoaging evidence than tretinoin, but studies show anti-aging potential.
0.1–0.3%
Irritation potential
MediumAllergen risk
LowPregnancy
AvoidSuitable for
Use with caution
Adapalene is not recommended during pregnancy. Consider an alternative from the same category.
Adapalene suits: oily, combination, normal. Use with caution in: sensitive, dry.
Adapalene has moderate irritation potential. Sensitive skin may show a transient reaction that usually settles with adaptation.
Third-generation synthetic retinoid.
The INCI name is Adapalene. It may also appear as: Differin.
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0.1–0.3%