Antibacterial agent that kills C. acnes by generating oxygen free radicals. Does not induce antibiotic resistance – a key advantage over antibiotics.
Topical application
AProven efficacy. Two or more independent RCTs with instrumental endpoints.
One of the most studied acne treatments. Meta-analyses confirm reduction of inflammatory and non-inflammatory lesions. Combination with adapalene (Epiduo) provides synergistic effect. FDA approved as OTC.
2.5–10% (2.5% works as well as 10% with less irritation)
Irritation potential
HighAllergen risk
ModeratePregnancy
CautionFor sensitive skin
Dries the skin and may cause peeling. Contact allergy develops in 1–2% of patients. Bleaches fabrics and hair.
Suitable for
Use with caution
Does not combine with
RetinolРетинол
Benzoyl peroxide oxidizes retinol, inactivating it. When both are needed – use at different times: BPO in morning, retinol at night.
TretinoinТретиноин
Classic incompatibility: BPO oxidizes tretinoin. Exceptions: micronized clindamycin+BPO (Duac) and adapalene+BPO (Epiduo) where formulation stability is engineered.
L-Ascorbic Acid (Vitamin C)L-Аскорбиновая кислота (витамин C)
BPO oxidizes ascorbic acid, inactivating it. Use at different times of day.
Benzoyl Peroxide should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
Benzoyl Peroxide suits: oily, combination. Use with caution in: sensitive, dry.
Yes, Benzoyl Peroxide has high irritation potential. Start at low concentrations, introduce gradually, and always use SPF during the day.
Antibacterial agent that kills C.
The INCI name is Benzoyl Peroxide.
Published: · updated:
2.5–10% (2.5% works as well as 10% with less irritation)