Retinoic acid – the most active topical form of vitamin A. A prescription drug and the gold standard for topical anti-aging and acne treatment.
Topical application
AProven efficacy. Two or more independent RCTs with instrumental endpoints.
Dozens of RCTs and meta-analyses confirm efficacy for photoaging, acne, and hyperpigmentation. Increases collagen synthesis, accelerates cell turnover, and normalizes desquamation. FDA-approved for acne and photodamage.
0.025–0.1% (prescription drug)
Start at 0.025% every other day, gradually transitioning to daily use. Adaptation takes 6–12 weeks.
Irritation potential
HighAllergen risk
LowPregnancy
AvoidFor sensitive skin
Retinoid dermatitis (peeling, redness, burning) is a normal adaptation response. Short-contact method (apply for 30 min, then rinse) helps reduce irritation.
Suitable for
Use with caution
Tretinoin is not recommended during pregnancy. Consider an alternative from the same category.
Tretinoin suits: normal, combination, oily. Use with caution in: sensitive, dry.
Yes, Tretinoin has high irritation potential. Start at low concentrations, introduce gradually, and always use SPF during the day.
Retinoic acid – the most active topical form of vitamin A.
The INCI name is Tretinoin. It may also appear as: All-Trans Retinoic Acid, Retin-A, Retinoic Acid.
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0.025–0.1% (prescription drug)