Gluconolactone (PHA)

INCI: Gluconolactone

Polyhydroxy acid (PHA) – a gentle AHA alternative. Its large molecular size slows penetration, reducing irritation. Also hydrates through hygroscopicity.

Anti-aging Moisturizing Brightening

Evidence by route

Topical application

Limited evidence. One RCT or several controlled studies with limitations.

Small clinical studies show exfoliating and moisturizing effects comparable to glycolic acid with significantly less irritation. Evidence base is weaker than for AHAs. No independent large RCTs.

Grimes PE et al. Cutis. 2004;73(2 Suppl):14-19.

Working concentrations

4–15%

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Caution

Skin types

Suitable for

SensitiveDryNormalCombination

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Frequently asked questions

Is Gluconolactone (PHA) safe during pregnancy?

Gluconolactone (PHA) should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.

What skin types is Gluconolactone (PHA) for?

Gluconolactone (PHA) suits: sensitive, dry, normal, combination.

What is Gluconolactone (PHA) and what does it do in cosmetics?

Polyhydroxy acid (PHA) – a gentle AHA alternative.

What's the INCI name for Gluconolactone (PHA)?

The INCI name is Gluconolactone. It may also appear as: D-Gluconic Acid Delta-Lactone, PHA, Глюконолактон.

What concentration of Gluconolactone (PHA) is effective?

4–15%

Published: April 13, 2026 · updated: May 17, 2026