Sphingolipid family of the stratum corneum; barrier component. Functional formulation ingredient with no standalone activity on the skin.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Inert formulation ingredient. Safe, no standalone activity.
Glycosphingolipids are a class of sphingolipids with a carbohydrate residue, a barrier component of the stratum corneum. They form part of keratinocyte lamellar bodies alongside ceramides and cholesterol – building the hydrophobic "cement" of the epidermal barrier. Where applied. Repair creams and serums for atopic and dry skin, barrier-positioned products. Often combined with ceramides and phytosphingosine – in La Roche-Posay Toleriane Sensitive, CeraVe, Bioderma Atoderm. Evidence base. Sphingolipids as a class have been studied in atopic dermatitis, psoriasis, eczema – fraction deficiency speeds up TEWL and worsens inflammation (Imokawa 1991). Direct RCTs of glycosphingolipids specifically are few; data come from ceramide-enriched formulas. Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic. Pregnancy and lactation – safe.
Irritation potential
LowAllergen risk
LowPregnancy
SafeThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Glycosphingolipids is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Sphingolipid family of the stratum corneum; barrier component.
The INCI name is Glycosphingolipids. It may also appear as: Гликосфинголипиды.
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