Retinoic acid ester known under the brand Granactive Retinoid. Irritates the skin less than retinol but also has a noticeably smaller clinical base.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A newer retinoid that binds retinoic acid receptors directly. Manufacturer studies show results comparable to retinol, but large independent RCTs are still few.
Irritation potential
MediumAllergen risk
LowPregnancy
AvoidSuitable for
Use with caution
Works well with
3-O-Ethyl Ascorbic Acid3-О-этил-аскорбиновая кислота
Granactive Retinoid (HPR) activates at neutral pH, so stable C forms pair well. With ethyl ascorbate, no irritation and no loss of activity for either molecule.
Ascorbyl TetraisopalmitateАскорбилтетраизопальмитат
HPR and THD ascorbate are both lipophilic and pH-neutral. Often formulated together in anhydrous anti-aging serums – convenient for retinoid adaptation.
Hydroxypinacolone Retinoate is not recommended during pregnancy. Consider an alternative from the same category.
Hydroxypinacolone Retinoate suits: oily, dry, combination, normal. Use with caution in: sensitive.
Hydroxypinacolone Retinoate has moderate irritation potential. Sensitive skin may show a transient reaction that usually settles with adaptation.
Retinoic acid ester known under the brand Granactive Retinoid.
The INCI name is Hydroxypinacolone Retinoate. It may also appear as: HPR, Granactive Retinoid.
Published: · updated: