Bioflavonoid from buckwheat, Japanese pagoda tree and citrus. Antioxidant, systemically – an angioprotective agent for venous insufficiency and couperose. Penetrates skin poorly because of a large glycoside moiety, so cosmetics more often use derivatives with better bioavailability.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
In vitro antioxidant profile is strong, but topical bioavailability is low. For visible effect on vascular network derivatives like troxerutin and hydroxypropyltrimonium conjugates are clinically more convincing.
Rutin (Rutoside, Quercetin-3-rutinoside) is a bioflavonoid from buckwheat, Japanese pagoda tree, citrus, and rowan. A quercetin glycoside with the disaccharide rutinose. Systemically (Venoruton, Anavenol oral preparations) used for chronic venous insufficiency and capillary fragility. On skin – an angioprotectant and antioxidant. Where applied. Anti-redness face creams and serums, products for rosacea patients, eye-contour products, anti-aging formulas (0.1-2%). In Spain – in Sesderma Daeses, Mussvital, certain La Roche-Posay sensitive-skin lines. Bioavailability – the bottleneck. The rutin molecule is large due to the rutinose moiety and penetrates intact epidermis poorly. Cosmetics more often use alpha-glucosyl rutin or hydroxyethyl rutosides – derivatives with better lipophilicity and penetration. The label form matters. Evidence base. Pancorbo 2017 in endothelial cell cultures showed reinforcement of the capillary wall and reduced permeability. Systemically – Cesarone 2010 (n=312) showed improvement in chronic venous insufficiency symptoms after 4 weeks of intake. Topical clinical RCTs for the face are isolated; for couperose and rosacea it is used by analogy with the systemic effect. Safety. CIR confirmed safety of rutin and its derivatives in cosmetics (Final Report 2014). Hypoallergenic, non-comedogenic. Systemic side effects from oral use are rare (dyspepsia, headache). Topically – no significant issues. Pregnancy and lactation – topically safe. Oral rutin in pregnancy (for venous insufficiency and hemorrhoids) is acceptable from the second trimester at the treating physician's decision; cosmetic forms have no restrictions.
Irritation potential
LowAllergen risk
LowPregnancy
SafeThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Rutin is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Rutin suits: normal, dry, combination, oily, sensitive.
Bioflavonoid from buckwheat, Japanese pagoda tree and citrus.
The INCI name is Rutin. It may also appear as: Rutoside, Quercetin-3-rutinoside, Рутин.
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