A natural moisturizing factor (NMF) present in the stratum corneum. Low concentrations moisturize; high concentrations act as a keratolytic. The gold standard for hyperkeratosis and xerosis.
Topical application
AProven efficacy. Two or more independent RCTs with instrumental endpoints.
Dozens of RCTs and dermatological society guidelines confirm efficacy for xerosis, atopic dermatitis, and hyperkeratosis. Reduces TEWL, restores NMF, and enhances penetration of other active ingredients.
2–10% for hydration; 20–40% for keratolytic effect
Irritation potential
LowAllergen risk
LowPregnancy
SafeFor sensitive skin
At concentrations above 10%, it may sting on damaged or inflamed skin. Start at 5%.
Suitable for
Urea is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Urea suits: dry, normal, sensitive, combination.
A natural moisturizing factor (NMF) present in the stratum corneum.
The INCI name is Urea. It may also appear as: Carbamide, Мочевина.
2–10% for hydration; 20–40% for keratolytic effect
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