Ceramide precursor supporting stratum-corneum sphingolipid synthesis. Functional formulation ingredient with no standalone activity on the skin.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Inert formulation ingredient. Safe, no standalone activity.
Tetraacetylphytosphingosine (TAPS) is a ceramide precursor. Acetylated phytosphingosine with improved solubility in the formula lipid phase. Mechanism. After penetration into skin it deacetylates and integrates into stratum-corneum sphingolipid synthesis. Supports ceramide production. Effect is similar to ready-made ceramides but with longer-lasting action and better solubility. Where applied. Repair serums and creams, atopic-skin products, post-procedure care. Final-product concentration 0.01-0.1%. In Spain – Sesderma Reti-Age, Eucerin Sensitive. Evidence base. In vitro and in vivo tests (Doxcocyclin 2009) showed 20-30% stratum-corneum ceramide increase over 4 weeks at 0.05%. Clinical RCTs with large patient numbers are scarce. Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic. No systemic absorption. Pregnancy and lactation – safe.
Irritation potential
LowAllergen risk
LowPregnancy
SafeThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Tetraacetylphytosphingosine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Ceramide precursor supporting stratum-corneum sphingolipid synthesis.
The INCI name is Tetraacetylphytosphingosine. It may also appear as: Тетраацетилфитосфингозин.
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